Li Xin

Subject: Organic Chemistry

Address:Room 313, 6th Buiding, 94 Weijin Road, Tianjin, 300071

Telephone: 13820943109

E-Mail: xin_li@nankai.edu.cn

Website: poc.nankai.edu.cn

Research Interest:
(1) to develop viable and reliable chiral small molecular catalysts with broad synthetic applications, (2) to disclose the underlying catalytic mechanism and principle as well as the connections between molecular recognition/assembly and selective catalysis.

History:
1998.9-2002.7 B.Sc. Department of Chemistry, Nankai University,
Advisor: Professor J. –P. Cheng
2002.9-2007.7 Ph.D. Department of Chemistry, Nankai University,
Advisor: Professor J. –P. Cheng
2007.9-2009.7 postdoctoral fellow, Institute of Chemistry, Chinese Academy of Sciences
Advisor: Professor S. Z. Luo
2009.7-2009.12 Assistant Professor, Institute of Chemistry, Chinese Academy of Sciences
2010.1-2010.8 Associate Professor, Institute of Chemistry, Chinese Academy of Sciences
2010.9-present Associate Professor, Department of Chemistry, Nankai University

Honors and Awards:
“New Century Excellent Talents in University” (2012)

Selected publications:
[1] W. Zhang, X.-X. Xiang, J. Chen, C. Yang, Y.-L. Pan, J. –P. Cheng, Q. Meng,* X. Li,* “Direct C-H Difluoromethylation of Heterocycles via Organic Photoredox Catalysis”, Nat. Commun. 2020, 11, 638-647.
[2] Q. Zhang, Y. Li, J. Wang, C. Yang, C.-J. Liu, X. Li,* J. –P. Cheng, “B(C6F5)3/Chiral Phosphoric Acid Catalyzed Ketimine-ene Reaction of 2-Aryl-3H-indol-3-ones and ?-Methylstyrenes”, Angew. Chem. Int. Ed. 2020, 59, 4550-4556.
[3] Y.-L. Pan, H. Zheng, J. Wang, C. Yang, X. Li,* J. –P. Cheng, “Enantioselective Allylation of Oxocarbenium Ions Catalyzed by Bi(OAc)3/Chiral Phosphoric Acid”, ACS Catal. 2020, 10, 8069-8076.
[4] G. –H. Yang, H. Zheng, X. Li,* J. –P. Cheng, “Asymmetric Synthesis of Axially Chiral Phosphamides via Atroposelective N-allylic Alkylation”, ACS Catal. 2020, 10, 2324-2333.
[5] G. –H. Yang, Y. Li, X. Li,* J. –P. Cheng, “Access to P-Chiral Phosphine Oxides by Enantioselective Allylic Alkylation of Bisphenols”, Chem. Sci. 2019, 10, 4322-4327.
[6] J. Wang, Q. Zhang, B. Zhou, C. Yang, X. Li,* J. –P. Cheng, “Bi(III)-Catalyzed Enantioselective Allylation Reactions of Ketimines” iScence, 2019, 16, 511-523.
[7] S. Li, C. Yang, Q. Wu, X. Li,* J. –P. Cheng, “Atroposelective Catalytic Asymmetric Allylic Alkylation Reaction for Axially Chiral Anilides with Achiral Morita–Baylis–Hillman Carbonates” J. Am. Chem. Soc. 2018, 140, 12836-12843.
[8] C. Yang, E. Zhang, X. Li,* J. –P. Cheng,* “Asymmetric Conjugate Addition of Benzofuran-2-ones to Alkyl 2-Phthalimidoacrylates: Modeling Structure-Stereoselectivity Relationship Using Steric and Electronic Parameters”, Angew. Chem. Int. Ed. 2016, 55, 6506-6510.
[9] N. Dong, Z. –P. Zhang, X. S. Xue, X. Li,* J. –P. Cheng, “Phosphoric Acid Catalyzed Asymmetric 1,6-Conjugate Addition of Thioacetic Acid to para-Quinone Methides”, Angew. Chem. Int. Ed. 2016, 55, 1460-1464.