Name
 Xi Zhen
Gender
 Male
Academic Background
 Doctor degree
Graduate School
 Uppsala University
Professional Title
 professor
Administrative Post
 director of research center
Department/Institute
 Institute of Elemento-organic Chemistry
Special Talent
 Cheung Kong Scholar Distinguished Professor
Address
 Rm 102, Institute of Elemental-Organic Chemistry, Nankai University, 94# Weijin Road, Tianjin 300071, China
Telephone
 23504782
Email
 zhenxi@nankai.edu.cn
Research Group Website
Research Interest
 1. Chemical Biology of Nucleic Acids；
2. Molecular Basis of Pesticide Resistance；
3. QSAR on Biomolecular Selectivity and Drug Resistance.
History
 B.S, 1983, Central China Normal University;
M.S, 1988, Nankai University;
Ph.D, 1994, Uppsala University;
Research Fellow, 1994-2001, Harvard Medical School
Professor, 2001-present, Nankai University, China.
Honors and Awards
 Eli Liley Research Excellence Award (China), 2006.
National Outstanding Oversea Returnee, 2009.
Tianjin Labor Medal, 2010.
Scientific Achievements & Selected Publications
1.5-Formylcytosine Yields DNA-Protein Cross-Links in Nucleosome Core Particles, F.-C. Li, Y.-Q. Zhang, J. Bai, M.-M. Greenberg, Z. Xi, C.-Z. Zhou, J. Am. Chem. Soc. 2017, 139, 10617-10620.
2.Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones, Y.-Q. Zhang, X.-P. Zhou, Y.-H. Xie, M.-M. Greenberg, Z. Xi, C.-Z. Zhou, J. Am. Chem. Soc. 2017, 139, 6146-6151.
3.A New H2S-specific Near-infrared Fluorescence-enhanced Probe That Can Visualize the H2S Level in Colorectal Cancer Cells in Mice, K. Zhang, J. Zhang, Z. Xi, L.-Y. Li, X.-X. Gu, Q.-Z. Zhang, L. Yi, Chem. Sci. 2017, 8, 2776-2781.
4.A Redox-Nucleophilic Dual-Reactable Probe for Highly Selective and Sensitive Detection of H2S: Synthesis, Spectra and Bioimaging, C.-Y. Zhang, R.-Y. Wang, L.-H. Cheng, B.-J. Li, Z. Xi, L. Yi, Sci. Rep. 2016, 6, 30148.
5.Dual-Reactable Fluorescent Probes for Highly Selective and Sensitive Detection of Biological H2S, C. Wei, R.-Y. Wang, C.-Y. Zhang, G.-C. Xu, Y.-Y. Li, Q.-Z. Zhang, L.-Y. Li, L. Yi, Z. Xi, Chem. Asian J. 2016, 11, 1376-1381.
6.Fast-Response Turn-on Fluorescent Probes Based on Thiolysis of NBD Amine for H2S Bioimaging, R.-Y. Wang, Z.-F. Li, C.-Y. Zhang, Y.-Y. Li, G.-C. Xu, Q.-Z. Zhang, L.-Y. Li, L. Yi, Z. Xi, ChemBioChem. 2016, 17, 962-968.
7.Branch-PCR Constructed Stable shRNA Transcription Nanoparticles Resulted in Long-lasting RNAi Effect, J.-B. Liu, R.-Y. Wang, D.-J. Ma, Y.-Y. Li, C. Wei, Z. Xi, ChemBioChem. 2016, 17, 1038-1042.
Flexible DNA Junction Assisted Efficient Construction of Stable Gene 8.Nanoparticles for Gene Delivery, J.-B. Liu, Y.-Y. Li, D.-J. Ma, D. Ouyang, Z. Xi, Chem. Comm. 2016, 52, 1953-1956.
9.A Dual-Response Fluorescent Probe Reveals the H2O2 -Induced H2S Biogenesis Through a Cystathionine Beta-Synthase Pathway, L. Yi, L. Wei, R.-Y. Wang, C.-Y. Zhang, J. Zhang, T.-W. Tan, Z. Xi, Chem. Eur. J. 2015, 21, 15167-15172.
10.A highly Selective and Fast-response Fluorescent Probe for Visualization of Enzymatic H2S Production in Vitro and in Living Cells, L. Wei, Z.-T. Zhu, Y.-Y. Li, L. Yi, Z. Xi, Chem. Comm. 2015, 51, 10463-10466.
11.Efficient Construction of Stable Gene Nanoparticles Through Polymerase Chain Reaction with Flexible Branched Primers for Gene Delivery, J.-B. Liu, R.-Y. Wang, D.-J. Ma, D. Ouyang, Z. Xi, Chem. Comm. 2015, 51, 9208-9211.
12.A FRET-ICT Dual-quenching Fluorescent Probe with Large Off-on Response for H2S: Synthesis, Spectra and Bioimaging, C.-Y. Zhang, L. Wei, C. Wei, J. Zhang, R.-Y. Wang, Z. Xi, L. Yi, Chem. Comm. 2015, 51, 7505-7508.
13.Self-assembled Controllable Virus-like Nanorods as Templates for Construction of One-dimensional Organic-inorganic Nanocomposites, D.-J. Ma, Y.-H. Xie, J. Zhang, D. Ouyang, L. Yi, Z. Xi, Chem. Comm. 2014, 50, 15581-15584.
14.FRET Ratiometric Probes Reveal the Chiral-sensitive Cysteine-Dependent H2S Production and Regulation in Living Cells, L. Wei, L. Yi, F.-B. Song, C. Wei, B.-F. Wang, Z. Xi, Sci. Rep. 2014, 4, 4521.
15.Understanding Resistance Mechanism of Protoporphyrinogen Oxidase-Inhibiting Herbicides: Insights from Computational Mutation Scanning and Site-Directed Mutagenesis, G.-F. Hao, Y. Tan, W.-F. Xu, R.-J. Cao, Z. Xi, G.-F. Yang, J. Agri. Food Chem. 2014, 62, 7209-7215.
16.o-Fluorination of Aromatic Azides Yields Improved Azido-Based Fluorescent Probes for Hydrogen Sulfide: Synthesis, Spectra, and Bioimaging, C. Wei, R.-Y. Wang, L. Wei, L.-H. Cheng, Z.-F. Li, Z. Xi, L. Yi, Chem. Asian J. 2014, 9, 3586-3592.
17.NBD-based Colorimetric and Fluorescent Turn-on Probes for Hydrogen Sulfide, C. Wei, Q. Zhu, W.-W. Liu, W.-B. Chen, Z. Xi, L. Yi, Org. Biomol. Chem. 2014, 12, 479-485.
18.Single Modification at Position 14 of siRNA Strand Abolishes Its Gene-silencing Activity by Decreasing Both RISC Loading and Target Degradation, J. Zheng, L. Zhang, J.-B. Zhang, X.-X. Wang, K.-Q. Ye, Z. Xi, Q. Du, Z.-C. Liang, FASEB J. 2013, 27, 4017-4026.
19.Quantitative Structural Insight into Human Variegate Porphyria Disease, B. -F. Wang, X. Wen, X.-H. Qin, Z.-F. Wang, Y. Tan, Y.-Q. Shen, Z. Xi, J. Biol. Chem. 2013, 288, 11731-11740.
20.Highly Potent and Stable Capped siRNAs with Picomolar Activity for RNA Interference, L. Wei, L,-Q. Cao, Z. Xi, Angew. Chem. Int. Ed. 2013, 52, 6501-6503.
Professional Cultivation