Name
Su Xun-Cheng
Gender
Male
Academic Background
Doctor degree
Graduate School
Colleage of Chemistry
Professional Title
professor
Administrative Post
Department/Institute
Institute of Elemento-organic Chemistry
Special Talent
Address
State Key Laboratory of Elemento-organic Chemistry, Weijin Road 94, Nankai University, Tianjin
Telephone
23500623
Email
xunchengsu@nankai.edu.cn
Research Group Website
http://skleoc.nankai.edu.cn/cms/item/view?table=team&id=576; http://skleoc.nankai.edu.cn/cms/item/searchpaper?account=suxuncheng
Research Interest
Chemical biology and structural biology:
1. Design and synthesis of small and  probes in chemical biology
2. Chemistry of protein modifications
3. Fragment based drug design by NMR spectroscopy
4. Paramagnetic NMR in structural biology and chemical biology
History
PhD (with Professor Chen Yun-Ti), Nankai University (2001)
Postdoctoral (with Professor Ivano Bertini and Lucia Banci), Center of Magnetic Resonance, University of Florence, Italy (2001-2004)
Research fellow (with Professor Gottfried Otting), Australian National University, Australia (2004-2010)
Professor, State Key Laboratory of Elemento-organic Chemistry (2010)
Honors and Awards

Scientific Achievements & Selected Publications
1. Li X., Wu G., Yang Y., Fu S., Liu X., Kang H., Yang X.*, Su X. C.*, Shen Y*. Calmodulin dissociates the STIM1-Orial complex and STIM1 oligomers. Nat. Commun. 2017, 8: 1042.
2. Gao J, Liang E, Ma R, Li F, Liu Y, Liu J, Jiang L, Li C, Dai H, Wu J, Su X. C., He W*, Ruan K*. Fluorine Pseudocontact Shifts Used for Characterizing the Protein-Ligand Interaction Mode in the Limit of NMR Intermediate Exchange. Angew. Chem. Int. Ed. Engl. 2017, 56, 12982-12986.
3. Yang Y., Gong Y. J., Litinov A., Liu H. K., Yang F., Su X. C.*, Goldfarb D*. Generic Tags for Mn(II) and Gd(III) spin labels for distance measurements in proteins. Phys. Chem. Chem. Phys. 2017, 19, 26944-26956.
4. Cao C, Wang S, Cui T, Su X. C.*, Chou J*. Ion and inhibitor binding of the double-ring ion selectivity filter of the Mitochondrial calcium uniporter. Proc. Natl. Acad. Sci. USA, 2017, 114, E2846-E2851.
5. Yang Y, Yang F, Gong Y. J., Chen J. l., Goldfarb D.*, Su X. C.*. A reactive, rigid Gd(III) labelling tag for in-cell EPR distance measurements in proteins. Angew. Chem. Int. Ed. Engl. 2017, 56, 2914-2918.
6. Ma FH, Wang X, Chen JL, Wen X, Sun H*, Su XC*. Deciphering the multisite interactions of a protein and its ligand at atomic resolution by using sensitive paramagnetic effects. Chem. Eur. J. 2017, 23, 926-934.
7. Li ML, Yang S, Su XC, Wu HL, Yang LL, Zhu SF, Zhou QL*. Mechanism Studies of Ir-Catalyzed Asymmetric Hydrogenation of Unsaturated Carboxylic Acids. J. Am. Chem. Soc. 2017, 139, 541-547.
8. Chen JL, Wang X, Yang F, Cao C, Otting G, Su XC*. 3D Structure determination of an unstable transient enzyme intermediate by paramagnetic NMR spectroscopy. Angew. Chem. Int. Ed. Engl. 2016, 55, 13744-13748.
9. Yang F, Wang X, Pan BB, Su XC*. Single-armed phenylsulfonated pyridine derivative of DOTA is rigid and stable paramagnetic tag in protein analysis. Chem. Commun. 2016, 52, 11535-11538.
10. Pan B. B., Yang F. Ye Y., Wang J. T., Li C.*, Huber T.*, Su XC*. Structural determination of proteins in living cells by paramagnetic NMR spectroscopy. Chem. Commun. 2016, 52, 10237-10240.
11. Ma RS, Li QF, Wang AD, Zhang JH, Liu ZJ, Wu JH, Su XC*, Ruan K*. Determination of pseudocontact shifts of low-populated excited states by NMR chemical exchange saturation transfer. Phys. Chem. Chem. Phys. 2016, 18, 13794-13798.
12. Yang Y, Huang F, Huber T, Su XC*. Site-specific tagging proteins with a rigid, small and stable transition metal chelator, 8-hydroxyquinoline, for paramagnetic NMR analysis. J. Biolmol. NMR 2016, 64, 102-113.
13. Chen JL, Yang Y, Zhang LL, Liang H, Huber T*, Su XC*, Otting G*. Analysis of the solution conformations of T4 lysozyme by paramagnetic NMR spectroscopy. Phys. Chem. Chem. Phys. 2016, 18, 5850-5859.
14. Martorana A, Yang Y, Zhao Y, Li QF, Su XC*, Goldfarb D*. Mn(II) tags for DEER distance measurements in proteins via C-S attachment. Dalton 2015, 44, 20812-20816.
15. Yang Y, Wang JT, Pei YY, Su XC*. Site-specific tagging proteins via a rigid, stable and short thiolether tether for paramagnetic spectroscopic analysis. Chem. Commun. 2015, 51, 2824-2827.
16. Wang Z, Yang X, Guo S, Yang Y, Su XC, Shen Y, Long J. Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. J. Biol. Chem. 2014, 289, 27376-27385.
17. Cao C, Chen JL, Yang Y, Huang F, Otting G, Su XC*. Selective 15N-labeling of the side-chain amide groups of asparagine and glutamine for applications in paramagnetic NMR spectroscopy. J. Biomol. NMR. 2014, 59, 251-261.
18. Ma FH, Chen JL, Li QF, Su XC*. Kinetic assay of Michael addition like thiol-ene reaction and the insight into protein bioconjugation. Chem. Asian J. 2014, 9, 1808-1816.
19. Yang Y, Chen JL, Su XC*. PCS in structural biology. Chin. J. Magn. Reson. (杨茵，陈家良，苏循成*. 蛋白质顺磁标记技术与生物核磁共振中的赝接触位移，波谱学杂志) 2014, 31, 155-171.
20. Su XC, Wang Y, Yagi H, Shishmarev D, Mason CE, Smith PJ, Vandevenne M, Dixon NE, Otting G*. Bound or free: interaction of the C-terminal domain of Escherichia coli single-stranded DNA-binding protein (SSB) with the tetrameric core of SSB. Biochemistry 2014, 52, 1925-1934.
21. Shishmarev D, Wang Y, Mason CE, Su XC, Oakley AJ, Graham B, Huber T, Dixon NE, Otting G*. Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy. Nucleic Acids Res. 2014, 42, 2750-2757.
22. Huang F, Pei YY, Zuo HH, Chen JL, Su XC*. Bioconjugation of proteins with a paramagnetic NMR and fluorescent tag. Chem. Eur. J. 2013, 19, 17141-17149.
23. Wei Z, Yang Y, Li QF, Huang F, Zuo HH, Su XC*. Noncovalent tagging proteins with paramagnetic lanthanide complexes for protein study. Chem. Eur. J. 2013, 19, 5758-5764.
24. Yang Y, Li QF, Cao C, Huang F, Su XC*. Site-specific labeling of proteins with a chemically stable, high-affinity tag for protein study. Chem. Eur. J. 2013, 19, 1097-1013.
25. Li J, Pilla KB, Li QF, Zhang Z, Su XC, Huber T, Yang J*. Magic angle spinning NMR structure determination of proteins from pseudocontact shifts. J. Am. Chem. Soc. 2013, 135, 8294-8303.
26. Zhou JY, Wan XJ, Liu YS, Zuo Y, Li Z, He GR, Long GK, Ni W, Li CS, Su XC, Chen YS*. Small molecules based on benzo[1,2-b:4,5-b ']dithiophene unit for high-performance solution-processed organic solar cells. J. Am. Chem. Soc. 2012, 134, 16345-16351.
27. Li QF, Yang Y, Maleckis A, Otting G*, Su XC*. Thiol-ene reaction: a versatile tool in site-specific labelling of proteins with chemically inert tags for paramagnetic NMR. Chem. Commun. 2012, 48, 2704-2706.
28. Su XC, Loh C-T, Ru Q, Otting G*. Suppression of isotope scrambling in cell-free protein synthesis by broadband inhibition of PLP enzymes for selective 15N-labelling and production of perduterated proteins in H2O. J. Biomol. NMR 2011, 50, 35-42.

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