Name |
Huang You |
Gender |
Male |
| Academic Background |
Doctor degree |
Graduate School |
Zhejiang University |
| Professional Title |
professor |
Administrative Post |
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Department/Institute |
Institute of Elemento-organic Chemistry |
Special Talent |
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Address |
94weijin Road, Institute of Elemento-organic Chemistry, Nankai University, Tianjin |
Telephone |
23503159 |
Email |
hyou@nankai.edu.cn |
Research Group Website |
https://hyou.scholar.group/ |
Research Interest |
Research Interest:
(1)Organophosphorus Chemistry .
(2)Organic Synthetic Chemistry
(3)Heteroatom Organic Chemistry
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History |
Education::
1982-1986 Department of Chemistry, Henan Normal University, Xinxiang, CHINA. Received B. Sc. Degree in June, 1986
1986-1989 Department of Chemistry, Henan Normal University, Xinxiang, CHINA. Received M. Sc. Degree in June, 1989
1994-1997 Department of Chemistry, Zhejiang(Hangzhou) University, Hangzhou, CHINA Received Ph.D. degree in June, 1997 (with Prof. Yongmin Zhang).
Academic Career:
1989-1994 Assistant professor and Lecturer, Department of Chemistry, Henan Normal University, Xinxiang, CHINA.
1997-1999 Postdoctoral associate, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA. (with Professor Ruyu Chen).
1999-2002 Postdoctoral associate, Graduate School of Pharmaceutical Sciences,Osaka University, Osaka, Japan. (with Professor Hidenobu Ohmori and Hatsuo Maeda)
2002-2008 Associate Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.
2008-2011 Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.
2011- Professor, State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.
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Honors and Awards |
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Scientific Achievements & Selected Publications
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Selected publications：
1. DABCO-Mediated [4 + 4]-Domino Annulation: Access to Functionalized Eight-Membered Cyclic Ethers
Liang, Ling; Li, Erqing; Dong, Xuelin; Huang You
Org. Lett. 2015, 17(19), 4914?4917.
2. Highly Enantioselective Intermolecular Cross Rauhut–Currier Reaction Catalyzed by a Multifunctional Lewis Base Catalyst
Dong, Xuelin; Liang, Ling; Li, Erqing and Huang You
Angew. Chem. Int. Ed. 2015, 54, 1621-1624. （Hot Paper）
3. Divergent Phosphine-Catalyzed [2+4] or [3+2] Cycloaddition Reactions ofγ-Substituted Allenoates with Oxadienes
Li, Erqing; Chang, Meijia; Liang, Ling and Huang You
Eur. J. Org. Chem. 2015, 710–714. （Hot Paper)
4. Morita–Baylis–Hillman adduct derivatives (MBHADs): versatile reactivity in Lewis base-promoted annulation
Xie, Peizhong and Huang You
Org. Biomol. Chem. 2015, 13(32), 8578–8595
5. A Sulfur Ylides-Mediated Domino Benzannulation Strategy to Construct Biaryls, Alkenylated and Alkynylated Benzene Derivatives
Gao Fei and Huang, You
Adv. Synth. Catal. 2014, 356, 2422-2428.
6 Phosphine-catalyzed Domino Reaction: A Novel Sequential [2+3] and [3+2] Annulation Reaction of γ-Substituent Allenoates to Construct Bicyclic[3, 3, 0]octene Derivatives.
Li, Erqing; Huang, You*
Chem. Commun., 2014, 50 (8), 948-950.
7 Sequential Catalyst Phosphine/Secondary Amine-Promoted [1+4]/ Rearrangement Domino Reaction for the Construction of (2H)-Pyrans and 2-oxabicyclo[2.2.2]oct-5-ene Skeletons
Xie, Peizhong; Yang, Jie; Zheng, Jie; Huang, You*
Eur. J. Org. Chem., 2014, 1189-1194.
8 Phosphine-Catalyzed Domino Reaction: A Novel Method Access to Functionalized
Bicyclic Skeletons
Li, Erqing; Huang, You*
Chem. Eur. J., 2014, 20, 3520
9 Phosphine Initiated Domino Reaction: A Convenient Method for the Preparation of Spiro-cyclopentanones
Liang, Ling; Li, Erqing; Xie, Peizhong; Huang You*
Chem. Asian J. 2014, 9(5), 1270-1273
10 Phosphine-Catalyzed Sequential [2 +3] and [3 + 2] Annulation Domino Reaction of γ- Benzyl Substituted Allenoates with α,β-Unsaturated Ketimines To Construct Aza-bicyclo[3, 3, 0]octane Derivatives
Li, Erqing; Jia, Penghao; Liang, Ling; Huang, You*
ACS Catal. 2014, 4, 600?603.
11 A simple and highly efficient procedure for construction of quaternary carbons centers by tributylphosphine catalyzed bis-Michael addition
Xu, Da-Zen; Zhan, Ming-Zhe; Huang, You*
Tetrahedron 2014, 70, 176-180
12. One step Synthesis of Benzoxazepine Derivatives via a PPh3 Catalyze aza-MBH Domino Reaction between Salicyl N-tosylimines and Allenoates.
Zhao, Hongxia; Meng, Xiangtai; Huang, You*
Chem. Commun., 2013, 49(89), 10513-10515.
(Highlighted by Prof. Snieckus, V and Guimar?es, K. G. in Synfacts 2014, 10(1), 0027)
13. Phosphine-Catalyzed Domino Reaction: An Efficient Method for the Synthesis of Bicyclo[3.2.0]heptenes Skeleton.
Zheng, Jie; Huang, You*; Li, Zhengming
Org. Lett. 2013, 15(22), 5758-5761.
14. Phosphine-Catalyzed Domino Benzannulation: An Efficient Method to Construct Biaryl Skeletons.
Zheng, Jie; Huang, You*; Li, Zhengming
Org. Lett. 2013, 15(19), 5064-5067.
15. Phosphine-Catalyzed [4+2] Annulation of gamma-Substituent Allenoates: Facile Access to
Functionalized Spirocyclic Skeletons.
Li, Erqing; Huang, You*; Liang, Ling; Xie Peizhong
Org. Lett. 2013, 15(12), 3138-3141.
16. Tunable Phosphine-Mediated Domino Reaction: Selective Synthesis of 2,3-Dihydrofurans and Biaryls
Xie, Peizhong; Li, Erqing; Zheng, Jie; Li, Xin; Huang, You*; Chen, Ruyu
Adv. Synth. Catal. 2013, 355(1), 161 – 169. （Hot Paper)
17. Tuning Catalysts to Tune the Products: Phosphine-Catalyzed Aza-Michael Addition Reaction of Hydrazones with Allenoates.
Li, Erqing; Xie, Peizhong; Yang, Lihua, Liang Ling, Huang You*.
Chem. Asian J. 2013, 8(3) , 603-610.
18. Phosphine-Catalyzed Rauhut-Currier Domino Reaction: A Facile Strategy for the Construction of Carbocyclic Spirooxindoles Skeletons
Hu, Chongchong; Zhang, Qinglong; Huang, You*
Chem. Asian J. 2013, 8(9) , 1981-1984
19. Domino Cyclization Initiated by Cross-Rauhut-Currier Reactions
Xie, Peizhong; Huang, You*
Eur. J. Org. Chem. 2013, (20), 6213–6226.
20. Sulfur Ylides Participating Domino Cyclization Reaction.
Li Gongchun; Wang Liye; Huang You*
Chin. J. Chem. 2013, 33(9), 1900-1918.
21. Phosphine-catalyzed Domino Reaction: an Efficient Method for the Synthesis of Highly Functionalized Spirooxazolines.
Yang, Lihua; Xie, Peizhong; Li, Erqing; Li, Xin; Huang, You*; Chen, Ruyu
Org. Biomol. Chem. 2012, 10(37), 7628-7634.
22. Phosphine-Catalyzed Rauhut-Currier Domino Reaction: A Facile Strategy for the Construction of Highly Functionalized Cyclopentene.
Hu, Chongchong; Geng, Zhishuai; Ma, Jianze; Huang, You*; Chen, Ruyu
Chem. Asian J. 2012, 7(9) , 2032-2035.
23. Phosphine-mediated Domino Benzannulation Strategy for the Construction of Highly Functionally Multi-aryl Skeletons
Xie, Peizhong; Huang, You*; Chen, Ruyu
Chem. Eur. J. 2012, 18(24), 7362-7366 (Most accessed article 2012.5)
24. Phosphine-Catalyzed Domino Reaction for the Synthesis of Conjugated 2,3-Dihydrofurans from Allenoates and Nazarov Reagents and the Mechanism Investigation
Xie, Peizhong; Lai, Wenqing; Geng Zhishuai; Huang, You*; Chen, Ruyu
Chem. Asian J. 2012, 7(7) , 1533-1537
25. Bifunctional phosphine-catalyzed Cross-Rauhut-Currier/Michael/Aldol Condensation Triple Domino Reaction: Synthesis of Functionalized cyclohexenes.
Xie, Peizhong; Huang, You*; Lai, Wenqing; Meng, Xiangtai; Chen, Ruyu.
Org. Biomol. Chem. 2011, 9(19), 6707-6714.
26. Domino Reaction for the Chemo- and Stereoselective Synthesis of Trans-2,3-Dihydrobenzofurans from N-Thiophosphinyl Iimines and Sulfur Ylides.
Xie, Peizhong; Wang, Liye; Yang, Lihua; Li, Erqing; Ma, Jianze; Huang, You*; Chen, Ruyu.
J. Org. Chem. 2011, 76(19), 7699-7705
27. Substrate-Controlled Phosphine-Catalyzed Domino Reactions of Activated Conjugated Dienes: Highly Diastereoselective Synthesis of Bicyclic Skeletons.
Ma, Jianze; Xie, Peizhong; Hu, Chongchong; Huang, You*; Chen, Ruyu.
Chem. Eur. J. 2011, 17(27), 7418-7422 （Hot Paper)
28. N-Heterocyclic Carbene-Catalyzed (NHC) Three-Component Domino Reactions: Highly
Stereoselective Synthesis of Functionalized Acyclic ε-Ketoesters.
Ma, Jianze; Huang, You*; Chen, Ruyu.
Org. Biomol. Chem. 2011, 9(6), 1791-1798
29. Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Ssynthesis of Trans-2,3-Dihydrobenzofurans from Salicyl N-Thiophosphinyl Imines and Allylic Carbonates.
Xie, Peizhong; Huang, You*; Chen, Ruyu.
Org Lett. 2010, 12(17), 3768-3771.
30. PPh3-Catalyzed Domino Reaction: A Facile Method for the Synthesis of Chroman Derivatives.
Meng, Xiangtai; Huang, You*; Zhao, Hongxia; Xie, Peizhong; Ma, Jianze; Chen, Ruyu.
Org. Lett. 2009, 11(4), 991-994.
31. Bifunctional Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Synthesis of cis-2,3-Dihydrobenzofurans from Salicyl N-Thiophosphinyl Imines and Allenes.
Meng, Xiangtai; Huang, You*; Chen, Ruyu.
Org Lett. 2009, 11(1), 137-140.
32. A Novel Selective aza-Morita-Baylis-Hillman (aza-MBH) Domino Reaction and aza-MBH Reaction of N-Sulfonated Imines with Acrolein Catalyzed by a Bifunctional Phosphine Organocatalyst.
Meng, Xiangtai; Huang, You*; Chen, Ruyu.
Chem. Eur. J. 2008, 14(23), 6852-6856.（Hot Paper， Most accessed article 2008.7)
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Professional Cultivation |
Groups：
Current Ph. D. Students: Li Ning，Feng Jiaxu, Chen Junlong, Zhu Yannan, Cai Wei， Zhou Yiming
Current Masters Students: Wang Dan, Lai Jingxiong, Lin Junhui
Current Undergraduate Students: Chen Yu, Chen YIngying, Qin Wenhui
Former Students:
Ph.D.
Meng Xiangtai(2009)
Xie Peizhong(2013)
Zheng Jie(2014)
Li Erqing(2015)
Dong Xuelin(2015)
Liang Ling(2016)
Zhang Qinglong(2017)
Jia Penghao(2018)
Jin Hongxing(2019)
M.S.：
Feng Dexin(2004)
Gu Yingchun(2006)
Wang Jinliang(2006)
Yu Yaqin(2007)
Xu Dazhen(2008)
Zhang Kui(2009)
Cui Meng(2009)
Zhao Hongxia(2010)
Shao Yongchen(2010)
Ma Jianze(2011)
Xiong QinPing(2011)
Wang Liye(2012)
Yang Lihua(2012)
Hu Chongchong(2013)
Gao Fei(2014)
Yang Jie(2015)
Chang Meijia(2016)
Wu Chengzhou(2017)
Yin Zhongmo(2018)
B.S.：
Xu Dazhen(2004)
Pan Lu(2005)
Zou Guanjun(2005)
Zhao Hongxia(2006)
Han Bailiang(2007)
He Dongming(2007)
Liu Tanglin(2008)
Lai Wenqing(2010)
Chen Yuchen(2010)
Geng Zhishuai(2012)
Chen Kaihong(2013)
Zheng Yanming(2015)
Li Ning(2016)
Zhang Yan(2016)
Tang Qingxuan(2017)
Xiu Wen(2017)
Wang Dan(2018)
Zhu Ziqi(2018)
Dai Changhang(2019)
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