Name
Wang, Bao-Lei
Gender
Male
Academic Background
Doctor degree
Graduate School
Nankai University
Professional Title
associate researcher
Administrative Post
Department/Institute
Institute of Elemento-organic Chemistry
Special Talent
Address
Room 405 of the Sixth Teaching Building, Institute of Elemento-Organic Chemistry, Nankai University, No. 94 Weijin Road, Tianjin 300071, China
Telephone
18920020912
Email
nkwbl@nankai.edu.cn
Research Group Website
Research Interest
Organic Chemistry, Pesticide Science
History
Dr. Baolei Wang received his Master of Science degree majoring in organic chemistry at Xinjiang University in 2001 under the supervision of Professor Fangming Liu. He obtained his Ph.D. degree in pesticide science at Nankai University in 2004 under the supervision of Professor Zhengming Li. Then he stayed in the research group of Professor Li working on the basic research of pesticide innovations and teaching for undergraduates at Nankai University. From 2015 to 2016, he served as a visiting scholar at University of Alberta performing research on new organic synthetic methodology under the supervision of Professor Frederick G. West related to cyclic allenes and the Nazarov electrocyclization chemistry. During his working in the Nankai University since 2004, he taught courses of “Organic Chemistry” and “Organic Chemistry Experiments”. His research work mainly focus on the design, synthesis and SAR study of novel organic compounds that have potential biological properties such as herbicidal, insecticidal and fungicidal activities, which target at special enzymes for crop protection use, e.g. ketol-acid reductoisomerase (KARI) and ryanodine receptor (RyR). Ha has chaired and accomplished the research work of his  Specialized Research Fund for the Doctoral Program of Higher Education and Tianjin Natural Science Fund projects; participated and received good achievements in a lot of projects, such as the national “863” and “973” programs, Australia international cooperation project, the National (Key) Natural Science Foundation of China, Tianjin University / Nankai University joint project, and cooperation research projects with Dow Chemical Company and Aberjona Laboratories, Inc.. Currently he is chairing two projects of the National Natural Science Foundation of China, one of the branch project of the National Key Research and Development Program of China, and one project of Tianjin Natural Science Foundation. He has more than 50 papers been published and 10 patents been applied. He now is a member of young editorial board of Chinese Chemical Letters, and reviewer of Journal of Agricultural and Food Chemistry, Phosphorus Sulfur and Silicon and the Related Elements, Chinese Journal of Chemistry, Chinese Journal of Organic Chemistry, etc.
Honors and Awards
In 2012, won the second prize of outstanding scientific research achievements in the Universities of Zhejiang Province.
Scientific Achievements & Selected Publications
Partial papers published listed as follows:
[28] Bao-Lei Wang*, Hong-Wei Zhu, Zheng-Ming Li, Li-Zhong Wang, Xiao Zhang, Li-Xia Xiong, Hai-Bin Song. Synthesis, Biological Evaluation and SAR Analysis of Novel Poly Heterocyclic Compounds Containing Pyridylpyrazole Group. Pest Manag. Sci., 2017, DOI: 10.1002/ps.4770.
[27] Bao-Lei Wang*, Li-Yuan Zhang, Xing-Hai Liu, Yi Ma, Yan Zhang, Zheng-Ming Li*, Xiao Zhang. Synthesis, biological activities and SAR studies of new 3-substitutedphenyl-4-substitutedbenzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2017, https://doi.org/10.1016/j.bmcl.2017.10.065.
[26] Bao-Lei Wang*, Yan Zhang, Xing-Hai Liu, Li-Yuan Zhang, Yi-Zhou Zhan, Xiao Zhang, Li-Zhong Wang, Yong-Hong Li, Zheng-Ming Li*. Synthesis and biological activity of novel dimethylpyrazole and piperazine-containing (bis)1,2,4-triazole derivatives. Phosphorus Sulfur Silicon Relat. Elem., 2017, 192, 34-41.
[25] Bao-Lei Wang, Yan-Xia Shi, Shu-Jun Zhang, Yi Ma, Hong-Xue Wang, Li-Yuan Zhang, Wei Wei, Xing-Hai Liu, Yong-Hong Li, Zheng-Ming Li*, Bao-Ju Li*. Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties. Eur. J. Med. Chem., 2016, 117: 167-178.
[24] Bao-Lei Wang*, Li-Yuan Zhang, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Li-Zhong Wang, Zheng-Ming Li*. Synthesis and biological activities of novel 1,2,4-triazole thiones and bis(1,2,4-triazole thiones) containing phenylpyrazole and piperazine moieties. J. Fluorine Chem., 2016, 184: 36-44.
[23] Yan Zhang, Xing-Hai Liu, Yi-Zhou Zhan, Li-Yuan Zhang, Zheng-Ming Li, Yong-Hong Li, Xiao Zhang, Bao-Lei Wang*. Synthesis and biological activities of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2016, 26: 4661-4665.
[22] Bao-Lei Wang*, Yi-Zhou Zhan, Li-Yuan Zhang, Yan Zhang, Xiao Zhang, Zheng-Ming Li*. Synthesis and fungicidal activities of novel 1,2,4-triazole thione derivatives containing 1,2,3-triazole and substituted piperazine moieties. Phosphorus Sulfur Silicon Relat. Elem., 2016, 191: 48-54.
[21] Li-Yuan Zhang, Bao-Lei Wang*, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Zheng-Ming Li*. Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives. Chin. Chem. Lett., 2016, 27: 163-167.
[20] Li-Yuan Zhang, Bao-Lei Wang*, Yi-Zhou Zhan, Xue-Wen Hua, Ming Liu, Xiao Zhang, Hai-Bin Song, Zheng-Ming Li*. Synthesis and biological activity of novel N-glucosides containing substituted piperazine moiety. Lett. Drug Des. Discov., 2016, 13 (4): 343-351.
[19] Yizhou Zhan, Baolei Wang*, Liyuan Zhang, Yan Zhang, Xiao Zhang, Zhengming Li*, Haibin Song. Studies on the Synthesis, Structure and Biological Activities of Novel Arylaminoformyl-containing 1-Cyano-1-cycloproane Carboxylic Acid Amides Based on Ugi Reaction. Acta Chim. Sinica, 2015, 73, 1173-1181.
[18] Baolei Wang, Yanxia Shi, Yizhou Zhan, Liyuan Zhang, Yan Zhang, Lizhong Wang, Xiao Zhang, Yonghong Li, Zhengming Li*, Baoju Li*. Synthesis and Biological Activity of Novel Furan/Thiophene and Piperazine-Containing (Bis)1,2,4-triazole Mannich Bases. Chin. J. Chem., 2015, 33(10): 1124-1134.
[17] Bao-Lei Wang*, Jing Wu, Qiao-Xia Liu, Yong-Hong Li, Hai-Bin Song, Zheng-Ming Li*. Synthesis, structure, and biological activities of [5-(arylthio/sulfinyl/sulfonyl)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2015, 190(1): 66-78.
[16] Bao-Lei Wang*, Qing-Nan Li, Yi-Zhou Zhan, Li-Xia Xiong, Shu-Jing Yu, Zheng-Ming Li*. The synthesis and biological activities of [5-(4-substituted phenylsulfinyl/sulfonyl)-1,3-dimethyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2014, 189: 483–491.
[15] Bao-Lei Wang, Hong-Wei Zhu, Yi Ma, Li-Xia Xiong, Yong-Qiang Li, Yu Zhao, Ji-Feng Zhang, You-Wei Chen, Sha Zhou, Zheng-Ming Li*. Synthesis, Insecticidal Activities, and SAR Studies of Novel Pyridylpyrazole Acid Derivatives Based on Amide Bridge Modification of Anthranilic Diamide Insecticides. J. Agric. Food Chem., 2013, 61: 5483-5493.
[14] Zhang, Ji-Feng ; Liu, Chen; Ma, Yi; Wang, Bao-Lei*; Xiong, Li-Xia; Yu, Shu-Jing; Li, Zheng-Ming*. Synthesis of Novel 3-Chloropyridin-2-yl-Pyrazole Derivatives and their Insecticidal, Fungicidal Activities and QSAR Study. LETTERS IN DRUG DESIGN & DISCOVERY, 2013, 10(6): 497-506.
[13] Wang Baolei, Ma Yi, Xiong Lixia, Li Zhengming. Synthesis and Insecticidal Activity of Novel N-Pyridylpyrazole Carbonyl Thioureas. Chin. J. Chem., 2012, 30: 815-821.
[12] Ji-Feng Zhang, Jun-Ying Xu, Bao-Lei Wang, Yu-Xin Li, Li-Xia Xiong, Yong-Qiang Li, Yi Ma, Zheng-Ming Li. Synthesis and Insecticidal Activities of Novel Anthranilic Diamides Containing Acylthiourea and Acylurea. J. Agric. Food Chem., 2012, 60: 7565-7572.
[11] Wang Bao-Lei, Liu Xing-Hai, Zhang Xiu-Lan, Zhang Ji-Feng, Song Hai-Bin, Li Zheng-Ming*. Synthesis, Structure and Biological Activity of Novel 1,2,4-Triazole Mannich Bases Containing a Substituted Benzylpiperazine Moiety. Chem. Biol. Drug Des., 2011, 78: 42-49.
[10] Wang, Bao-Lei; Shi, Yan-Xia; Ma, Yi; Liu, Xing-Hai; Li, Yong-Hong; Song, Hai-Bin; Li, Bao-Ju*; Li, Zheng-Ming*. Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis(1,2,4-Triazole) Mannich Bases Containing Piperazine Rings. Journal of Agricultural and Food Chemistry 2010, 58(9): 5515-5522.
[9] Wang, B. L.; Ma, R. D.; Li, Y. H.; Song, H. B.; Li, Z. M. Synthesis, Structure and Biological Activity of 2- 4-(5-Substituted-1,3,4-oxadiazol-2-yl)phenoxy Propanoate/Acetate. Chinese Journal of Organic Chemistry 2010, 30(1): 92-97.
[8] Wang, B. L.; Liu, X. H.; Li, Z. M., Synthesis and Characterization of O,O-Dimethyl-N-(2,2,2-trichloro- 1-arylaminoethyl) Phosphoramidothioates. Phosphorus Sulfur and Silicon and the Related Elements 2009, 184(9): 2281-2287.
[7] Bao-Lei Wang, Yong-Hong Li, Jian-Guo Wang, Yi Ma, Zheng-Ming Li. Molecular design, synthesis and biological activities of amidines as new ketol-acid reductoisomerase inhibitors. Chin. Chem. Letts., 2008, 19: 651-654.
[6] WANG Bao-Lei, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Synthesis and Herbicidal Activities of 4-Alkoxy/benzyloxyphenyltetrazoles and 1,3,4-Oxadiazoles. Chem. J. Chin. U., 2008, 29(1): 90-94.
[5] Bao-Lei Wang, Zheng-Ming Li, Yong-Hong Li, Su-Hua Wang. Syntheses and biological activities of ethyl N-hydroxy-N-(substituted)phenyloxamates as KARI inhibitors. Chem. Res. Chin. U., 2007, 23(3): 280-283.
[4] Bao-Lei Wang, Ronald G Duggleby, Zheng-Ming Li, Jian-Guo Wang, Yong-Hong Li, Su-Hua Wang, Hai-Bin Song.
Synthesis, crystal structure and hebricidal activity of mimics of intermediates of the KARI reaction. Pest Management Science, 2005, 61: 407-412.
[3] WANG Bao-Lei, WANG Jian-Guo, MA Yi, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Molecular Docking and 3D-QSAR Research of Amidines of KARI Inhibitor. Acta Chimica Sinica, 2006, 64(13): 1373-1378.
[2] WANG Bao-Lei, LI Zheng-Ming, MA Yi, WANG Jian-Guo, LUO Xiao-Min, ZUO Zhi-Li. 3D-Database Searching Based on the Crystal Structure of Ketol-acid Reductoisomerase (KARI) Complex. Chin. J. Org. Chem., 2004, 24(8): 973-976.
[1] Wang Bao-Lei, Ma Ning, Wang Jian-Guo, Ma Yi, Li Zheng-Ming, Li Yong-Hong. 3D-QSAR Analysis of New Sulfonylureas Related to Their Herbicidal Activity. Acta Physico-chimica Sinica, 2004, 20(6): 577-581.

Partial authorized patents listed as follows:
[2] Wang, Baolei; Li, Zhengming; Zhang, Yan; Zhang, Liyuan; Zhang, Xiao; Li, Yonghong. Piperazine-containing 1,3,4-oxadiazole Mannich base compound as keto-acid reductoisomerase (KARI) inhibitor for prevention and treatment of weed and fungi attack on crops and its preparation. Faming Zhuanli Shenqing (2016), CN 105541748 A, 20160504.
[1] Li, Zhengming; Wang, Baolei; Zhang, Jifeng; Xu, Junying; Xiong, Lixia; Zhao, Yu; Wang, Gang. Preparation of N-aminothioxomethyl pyrazolecarboxamide derivatives as agricultural pesticides. Faming Zhuanli Shenqing (2011), CN 102276580 A, 20111214.
Professional Cultivation
Supervising postgraduates, and assisting Professor Zheng-Ming Li in supervising postgraduates and doctoral candidates. Thirteen master students and PhD students have graduated.