Name |
Liu Lingyan |
Gender |
Female |
| Academic Background |
Doctor degree |
Graduate School |
Nankai University |
| Professional Title |
associate researcher |
Administrative Post |
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Department/Institute |
Institute of Elemento-organic Chemistry |
Special Talent |
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Address |
221#，the institute of Elemento-Organic Chemistry, Nankai University, Weijin Road 94# |
Telephone |
022-23501410 |
Email |
liulingyan@nankai.edu.cn |
Research Group Website |
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Research Interest |
1. The related cascade reaction methodology of simple homopropargylic amine
2. The tandem cycloisomerization of 1,5-enynols
3. The small organic molecular catalyzed asymmetric reaction
4. The design, synthesis and properties study of functional and multi-sensitive polymers
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History |
1996-2000 the Central China Normal University, the department of chemistry, BS
2001-2007 the institute of Elemento-Organic Chemistry, Ph.D
2007-2011 the institute of Elemento-Organic Chemistry, Tutor
2012-present the institute of Elemento-Organic Chemistry, Associate Professor
2014-2015 the University of Wisconsin-Madison, the School of Pharmacy, Visiting Scholar
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Honors and Awards |
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Scientific Achievements & Selected Publications
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Presided or undertake 1 Key Project of Tianjin natural science fund and participate 1 National Key Research and Development Program of China, and had chaired 4 projects：1) national natural science foundation of China youth fund; 2) natural science fund of tianjin youth; 3) national natural science foundation of China Special fund; 4) Fundamental Research Funds for the Central Universities
In recent 5 years, I had published more than 20 papers in national Journal.
Publish：
(46) Xinhong Li, Songmeng Wang, Shengli Li, Kangming Li, Xin Mo, Lingyan Liu*, Weixing Chang, Jing Li*, The hydroamination cyclization [2+2]-cycloaddition cascade reactions of homopropargylic amines with 2-butynedioates: An access to the pyrrolo-b-cyclobutene and dihydro-1H-azepine J. Org. Chem. 2019, 84, 1288-1298.
(45) Weilin Wang, Yixin Fu, Yimeng Li, Ruitong Yao, Lingyan Liu, * Weixing Chang, Jing Li, Ag(I)-Catalyzed solvent-free CO2 capture with homopropargylic amines: an efficient access to 1,3-oxazinan-2-ones, Org. Chem. Front. 2018, 5, 3331-3335.
(44) Ming Zhang, Yongguang, Jia, Lingyan Liu, Jing Li, Xiaoxia Zhu, Soluble- Insoluble-Soluble Transitions of Cryptand-Containing Graft Copolymers, ACS Omega 2018, 3, 10172-10179.
(43) Jing Wu, Yuanfang Kong, Lingyan Liu*, Weixing Chang, Jing Li*, Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to the thiazine imides, Org. Biomol & Chem. 2018,16, 5955-5959.
(42) Lun Wang, Yuanfang Kong, Hongkai Wang, Hao Chen, Lingyan Liu*, Weixing Chang, Jing Li*, The PtCl2/FeCl3 cocatalyzed hydroamination cyclization-protonation / hydroalkoxyaltion nontypical Povarov cascade reactions of homopropargylic amines and arylalkynols, J. Org. Chem. 2018, 83, 7799-7813.
(41) Weilin Wang, Lingyan Liu*, Weixing Chang, Jing Li*, Copper Promoted Regio- and Stereoselective chloroamination of simple alkynes and alkenes with NFSI, Chem. Eur. J. 2018, 24, 8542-8547.
(40) Yuanfang Kong, Yingze Liu, Chunhui Jiang, Shuai Wang, Kediliya Wumaier, Lingyan Liu*, Weixing Chang, Jing Li*, The catalysts-controlled divergent cascade reactions of homo-propargylic amines and nitrones: Synthesis of pyrroloisoxazolidines and γ-lactam, Adv. Synth. Catal. 2018, 360, 1240-1252.
(39) Yuanfang Kong, Kediliya Wumaier, Chunhui Jiang, Yingze Liu, Shuai Wang, Lingyan Liu*, Weixing Chang, Jing Li*, Cu(OAc)2/TEMPO promoted hydroamination cyclization-anaerobic oxidative dehydrogenation cascade reaction of homopropargylic amines, Chem. Asian. J. 2018, 13, 46-54.
(38) Hao Chen, Chan Wang, Hongkai Wang, Lingyan Liu*, Weixing Chang, Jing Li*, The Diverse Reactivity of Homopropargylic Amines as “Masked” 1C Synthons for the Aza-Friedel–Crafts Alkylation of Indoles, Eur. J. Org. Chem. 2018, 470-476.
(37) Qiangqiang Liu, Chan Wang, Lingyan Liu*, Weixing Chang, Jing Li*, The Povarov reaction of cycloiminium formed in situ via hydroamination cycloisomerization of homopropargylic amines with electron-rich olefins J. Org. Chem. 2017, 82, 950-958.
(36) Hongkai Wang, Chan Wang, Kaimeng Huang， Lingyan Liu*, Weixing Chang, Jing Li*, Copper catalyzed cascade reaction via intramolecular hydroamination cyclization of homopropargylic amines and intermolecular Povarov reaction with imines Org. Lett. 2016, 18, 2367-2370.
(35) Kaimeng Huang, Hongkai Wang, Lingyan Liu,* Weixing Chang, and Jing Li* Mutual Cooperation in the Formal Allyl Alcohol Nucleophilic Substitution and Hydration of Alkynes for the Construction of γ-Substituted Ketones Chem. Eur. J. 2016, 22, 6458-6465.
(34) Ming Zhang, Yi Yang, Lingyan Liu, Weixing Chang, and Jing Li, Pseudo- Cryptand-Containing Copolymers: Cyclopolymerization and Biocompatible Water-Soluble Al3+ Fluorescent Sensor in Vitro Macromolecules, 2016, 49 (3), 844–852.
(33) Lingyan Liu, Chan Wang, Qiangqiang Liu, Yuanfang Kong, Weixing Chang, Jing Li,* Weiping Tang*, Cu(OTf)2 catalyzed hydroamination cyclization-dimerization cascade reaction of homopropargylic amines for the construction of complex fused nitrogen-containing tetracycles Eur. J. Org. Chem. 2016, 3684-3690.
(32) Ming Zhang, Lingyan Liu*, Weixing Chang, Jing Li*, Controllable and Reversible Dimple-Shaped Aggregates Induced by Macrocyclic Recognition Effect. Langmuir 2015, 31, 13581-13589.
(31) Xiaoxun Li, Hui Li, Wangze Song, Po-Sen Tseng, Lingyan Liu,* Ilia A. Guzei, and Weiping Tang*, Divergent Reactivity of Rhodium(I) Carbenes Derived from Indole Annulations, Angew. Chem. Int. Ed. 2015, 54, 12905-12908.
(30) Chan Wang, Kaimeng Huang, Junying Wang, Hongkai Wang, Lingyan Liu,* Weixing Chang, and Jing Li*, Synthesis of Tetrasubstituted Pyrroles from Homopropargylic Amines via aSonogashira Coupling/Intramolecular Hydroamination/Oxidation Sequence, Adv. Synth. Catal. 2015, 357, 2795-2802.
(29) Junying Wang, Kaimeng Huang, Lingyan Liu*, Weixing Chang, Jing Li*, Gold(I)-catalyzed cyclization ofo-(alkynyl)styrene ether mediated by MeOH for the construction of 2-aryl-1H-indene acetal, Tetrahedron Lett. 2015, 56, 2659–2663.
(28) Pingping Huang, Lingyan Liu,* Weixing Chang, and Jing Li* An Unexpected Double Diels–Alder Reaction of (E)-2-Bromo-4-aryl-1,3-pentadiene Involving [1,5]-Hydrogen Migration and HBr Elimination: Synthesis of Bicyclo[2.2.2]octene Derivatives, Chem. Asian J. 2015, 10, 548-552.
(27) Kaimeng Huang, Xiaona Ke, Hongkai Wang, Junying Wang, Chenchen Zhou, Xiufang Xu,* Lingyan Liu*, and Jing Li*, PtI2-catalyzed cyclization of 3-acyloxy-1,5-enynes with the elimination of HOAc and a benzyl shift: synthesis of unsymmetricalm-terphenyls, Org. Biomol. Chem., 2015, 13, 4486-4493.
(26) PingpingMiao, HongkaiWang, Lingyan Liu,* Weixing Chang, and Jing Li* Palladium-Catalyzed Highly Chemoselective Cascade CouplingCyclization of Allenol Derivatives and Aryl Halides for the Construction of Dihydrobenzofuranols or Chromanols and Indolinols, Asian J. Org. Chem. 2015, 4,1050-1054.
(25) Lingyan Liu,* Yunna Zhu, Kaimeng Huang, Bing Wang, Weixing Chang, Jing Li* Asymmetric Organocatalytic Quadruple Cascade Reaction of 2-Hydroxychalcone with Cinnamaldehyde for the Construction of Tetrahydro-6H-benzo[c]chromene Containing Five Stereocenters, Eur. J. Org. Chem. 2014, 4342-4350.
(24) Lingyan Liu,* Yan Zhang, Hua Zhang, Kaimeng Huang, Bo-xin Gao, Min Zou, Xin Zhou, Hongkai Wang and Jing Li* The metal tin promoted cascade reaction of ketone in aqueous media for the construction of 2-bromo-4-aryl-1,3-pentadiene, Org. Biomol. Chem., 2014, 12 (29), 5393-5399.
(23) Ling-yan Liu, Bing Wang, Yunna Zhu, Wei-xing Chang, Jing Li*, Additive-controlled Regioselectivity Direct Asymmetric Aldol Reaction of Hydroxyacetone and Aldehyde Tetrahedron: Asymmetry 2013, 24, 533-542.
(22) Lingyan Liu, Yunna Zhu, Kaimeng Huang, Weixing Chang, and Jing Li*, Organic Phosphine Based on L-proline Catalyzed Asymmetric Michael Addition of Cyclohexanone or Cyclopentanone to Chalcones, Eur. J. Org. Chem. 2013, 13, 2634-2645.
(21) Yong-Guang Jia, Jian Jiang, Ling-Yan Liu*, Wei-Xing Chang, Jing Li* Effect of Cross-Linker on Morphology, Catalytic Activity, and Recyclability of Immobilized Palladium Chloride, J. Appl. Polym. Sci. 2013, 128, 2604-2610.
(20) Yong-Guang Jia, Jian Jiang, Ling-Yan Liu*, Wei-Xing Chang, Jing Li Preparation and Characterization of Novel Organic/Inorganic Hybrid Nanoparticles Containing an Organotin Core and a Polystyrene Shell, J. Appl. Polym. Sci. 2012, 126: 56-65.
(19) Yong-guang Jia, X. X. Zhu*, Ling-yan Liu?, and Jing Li*, Multi-Responsive Properties of a Poly(Ethylene Glycol)-Grafted Alternating Copolymers of Distyrenic Monomer with Maleic Anhydride, Langmuir, 2012, 28 (9), 4500-4506.
(18) Feng, Gang; Jia, Yong-guang; Liu, Ling-yan*; Chang, Wei-xing; Li, Jing*, Well-defined polymers containing 1,3-dichloro-tetra-n-butyl-distannoxane moiety: Synthesis, mechanism, and applications in catalysis, J. Appl. Polym. Sci. 2012, 123, 3485-3494.
(17) Liu Ling-yan*, Zhang Yan, Huang Kai-meng, Chang Wei-xing, Jing Li*. 1,3-Dichloro-tetra-n-butyl-distannoxane: a new application for catalyzing the direct substitution of 9 H-xanthen-9-ol at room temperature, Appl. Organometal. Chem. 2012, 26, 9-15.
(16) Jia, Yong-guang; Liu, Ling-yan; Lei, Bin; Li, Jing*; Zhu, X. X.*, Crown Ether Cavity-Containing Copolymers via Controlled Alternating Cyclocopolymerization Macromolecules 2011, 44, 6311-6317.
(15) Liu, Ling-yan; Wang, Bing; Yang, Hong-mei; Chang, Wei-xing; Li, Jing*, The direct substitutions of 9H-xanthen-9-ol with indoles in a room temperature ionic liquid medium BmimBF4, Tetrahedron Lett. 2011, 52, 5636-5639.
(14) Lei, Bin; Jiang, Jian; Jia, Yong-guang; Liu, Ling-yan*; Chang, Wei-xing; Li, Jing*, Novel organotin-containing diblock copolymer with tunable nanostructures: Synthesis, self-assembly and morphological change, J. Organometal. Chem. 2011, 696, 1416-1424.
(13) Feng, Gang; Jia, Yong-guang; Liu, Ling-yan*; Chang, Wei-xing; Li, Jing*, Novel organotin-containing shell-cross-linked knedel and core-cross-linked knedel: Synthesis and application in catalysis, J. Polym. Sci. Part A: Polym. Chem. 2010, 48, 5992-6002.
(12) Wang, Xin; Liu, Ling-yan*; Chang, Wei-xing; Li, Jing*, Sequential Sonogashira/ Carbopalladative Cyclization/Suzuki Reactions Catalyzed by a Single Palladium Source by Using Protected Homopropargyl Alcohol, Eur. J. Org. Chem. 2010, 5391-5396.
(11) Wang, Bing; Liu, Xin-wang; Liu, Ling-yan*; Chang, Wei-xing; Li, Jing*, Highly Efficient Direct Asymmetric Aldol Reactions Catalyzed by a Prolinethioamide Derivative in Aqueous Media, Eur. J. Org. Chem. 2010, 5951-5954.
(10) Chen, Guo-hong; Liu, Ling-yan*; Wei, Xiao-ning; Chang, Wei-xing; Li, Jing*, Asymmetric Allylation of Aldehydes Catalyzed by Simple Dual Small Organic Molecules: L-Proline and L-Prolinol, Chem. Lett. 2010, 39, 1013-1015.
(9) Chen, Guo-hong; Wang, Xin; Jin, Xiao-qian; Liu, Ling-yan*; Chang, Wei-xing; Li, Jing*, Allyltin tribromide: A versatile reagent involved in the ring-opening of epoxides, Sci. Chin. Series B: Chem. 2010, 53, 1294-1301.
(8) Lei, Bin; Jia, Yong-guang; Liu, Ling-yan*; Chang, Wei-xing; Li, Ling*, Synthesis and Crystal Structure of Novel Sn–O Clusters Generated from nBu2SnO and Esters, Chin. J. Struct. Chem. 2010, 29: 1373-1379.
(7) Wang, Bing; Chen, Guo-hong; Liu, Ling-yan*; Chang, Wei-xing; Li, Jing*, A Novel Proline-Valinol Thioamide Small Organic Molecule for a Highly Enantioselective Direct Aldol Reaction, Adv. Synth.& Catal. 2009, 351, 2441-2448.
(6) Wang, Xin; Liu, Ling-yan*; Chang, Wei-xing; Li, Jing*, Sonogashira coupling reaction of homopropargyl ether with aryl bromides and synthesis of 2,5-disubstituted 3-bromofurans, Sci. Chin. Series B: Chem. 2009, 52, 1314-1320.
(5) Wei, Xiao-ning; Liu, Ling-yan*; Wang, Bing; Chang, Wei-xing; Li, Jing*, In(OTf)3 catalyzed allylation reaction of imines with tetraallyltin Chin. Chem. Lett. 2009, 20: 40-43.
(4) Wei, Xiao-ning; Liu, Ling-yan*; Wang, Bing; Chang, Wei-xing; Li, Jing, Allylation Reaction of Simple Imines by Organotin Reagents, Acta. Chimica Sinica 2009, 67, 833-837.
(3) Wei, Xiao-ning; Liu, Ling-yan*; Yu, Lei; Chang, Wei-xing; Li, Jing*, New Binuclear Allyla ting Reagents for Allylation of Aromatic Aldehydes, Chem. J. Chin. Univ. 2008, 29, 767-771.
(2) Liu, Ling-yan; Sun, Jing; Liu, Nan; Chang, Wei-xing; Li, Jing, A structurally simple l-proline derivative promotes the asymmetric allylation of aldehydes with tribromoallyltin, Tetrahedron: Asymmetry 2007, 18, 710-716.
(1) Liu, Ling-yan; Tang, Long; Yu, Lei; Chang, Wei-xing; Li, Jing, Indium triflate catalyzed allylation of ketones with diallyldibutyltin, Tetrahedron 2005, 61, 10930-10934.
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Professional Cultivation |
1 master graduates students, 1 graduated master studeng, used to guide 4 undergraduate 100-project, guided more than 10 undergraduate graduation thesis, and assisted to guide more than 20 doctoral and masters graduate students
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